| 开盘价:-- |
最高价:-- |
最低价:-- |
52周最高价:-- |
52周最低价:-- |
| 成交量:-- |
平均成交量:-- |
市值:-- |
市盈率:-- |
预期市盈率:-- |
| 每股收益:-- |
贝塔系数:-- |
股息:-- |
收益率:-- |
总股本:-- |
| 机构持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| Orbimed Advisors, LLC |
919249 |
1.97% |
333675 |
56.98% |
2022-03-31
|
| Aquilo Capital Management, LLC |
901490 |
1.93% |
225284 |
33.32% |
2022-03-31
|
| Macquarie Group Ltd |
707141 |
1.52% |
-- |
-- |
2022-03-31
|
| JPMorgan Chase & Co |
884820 |
1.90% |
174069 |
24.49% |
2022-03-31
|
| JPMorgan Asset Management (Europe) S.¨¤ r.l. |
744889 |
1.60% |
-6990 |
-0.93% |
2022-05-31
|
| Adage Capital Partners Gp LLC |
700000 |
1.50% |
100000 |
16.67% |
2022-03-31
|
| BlackRock Fund Advisors |
5793741 |
12.42% |
2008956 |
53.08% |
2022-05-31
|
| BlackRock Inc |
4293805 |
9.20% |
50307 |
1.19% |
2021-12-31
|
| SSGA Funds Management Inc |
4145607 |
8.89% |
-55360 |
-1.32% |
2022-05-31
|
| FMR Inc |
3793464 |
8.13% |
-546599 |
-12.59% |
2022-03-31
|
| Point72 Asset Management, L.P. |
3250300 |
6.97% |
1284780 |
65.37% |
2022-03-31
|
| State Street Corporation |
2813416 |
6.03% |
655732 |
30.39% |
2022-03-31
|
| Nantahala Capital Management, LLC |
2811459 |
6.03% |
448146 |
18.96% |
2022-03-31
|
| Fidelity SelectCo, LLC |
1814575 |
3.89% |
-332041 |
-15.47% |
2022-05-31
|
| Delaware Management Company |
1412332 |
3.03% |
-- |
-- |
2022-05-31
|
| Morgan Stanley - Brokerage Accounts |
1374179 |
2.95% |
132418 |
10.66% |
2022-03-31
|
| 683 Capital Management LLC |
1355000 |
2.90% |
101800 |
8.12% |
2022-03-31
|
| Vanguard Group Inc |
1209840 |
2.59% |
30053 |
2.55% |
2022-03-31
|
| Fidelity Management & Research Company LLC |
1076857 |
2.31% |
-188612 |
-14.90% |
2022-05-31
|
| Amvescap Plc. |
2374235 |
5.09% |
77856 |
3.39% |
2021-12-31
|
| Federated Hermes Inc |
1442842 |
3.09% |
-1846819 |
-56.14% |
2021-12-31
|
| BNY Mellon Investment Funds VII, Inc. |
732813 |
1.57% |
-5424 |
-0.73% |
2022-05-31
|
| T. Rowe Price Associates, Inc. |
1358709 |
2.91% |
-243457 |
-15.20% |
2021-12-31
|
| Fidelity Management Trust Company |
755205 |
1.62% |
-197132 |
-20.70% |
2022-04-30
|
| BNY Mellon Investment Adviser, Inc. |
732813 |
1.57% |
-5424 |
-0.73% |
2022-04-30
|
| Invesco Ltd (OFI / OppenheimerFunds) |
1031898 |
2.22% |
-103694 |
-9.13% |
2022-04-30
|
| Federated Global Investment Management Corp |
1426282 |
3.07% |
-1819058 |
-56.05% |
2022-04-30
|
| Federated Equity Mgmt Co. Of Penn |
796429 |
1.71% |
-762971 |
-48.93% |
2022-04-30
|
| FMR LLC |
4449609 |
9.58% |
4449609 |
-- |
2020-12-31
|
| Federated Hermes, Inc. |
3855615 |
8.30% |
3855615 |
-- |
2020-12-31
|
| Invesco Ltd |
3430893 |
7.39% |
3430893 |
-- |
2020-12-31
|
| Federated |
1700000 |
3.68% |
-- |
-- |
2022-01-31
|
| Citadel Advisors Llc |
1324299 |
2.87% |
27003 |
2.08% |
2021-06-30
|
| Invesco Advisers, Inc. |
1181878 |
2.56% |
-44674 |
-3.64% |
2021-08-31
|
| JP Morgan Asset Management (UK) Ltd |
994726 |
2.16% |
388398 |
64.06% |
2021-03-31
|
| Fidelity Management and Research Company |
4495716 |
9.76% |
115257 |
2.63% |
2021-03-31
|
| Invesco Advisers, Inc |
1023951 |
2.23% |
73286 |
7.71% |
2021-05-31
|
| Redmile Group, LLC |
1028898 |
2.24% |
-99929 |
-8.85% |
2020-12-31
|
| Janus Capital Management LLC |
1275934 |
2.84% |
641311 |
101.05% |
2021-04-30
|
| Marshall Wace Asset Management Ltd |
1537905 |
3.42% |
737928 |
92.24% |
2020-09-30
|
| venBio Select Advisor LLC |
1750000 |
3.93% |
250000 |
16.67% |
2020-09-30
|
| Fidelity Management Trust Co |
767565 |
1.73% |
18808 |
2.51% |
2020-12-31
|
| Boxer Capital LLC |
765400 |
1.72% |
-- |
-- |
2020-09-30
|
| Fidelity Management & Research Company LLC |
1405627 |
3.16% |
-551404 |
-28.18% |
2020-11-30
|
| UBS Asset Mgmt Americas Inc |
1005659 |
2.26% |
283243 |
39.21% |
2020-06-30
|
| Artal Group S A |
1000000 |
2.25% |
-150000 |
-13.04% |
2020-06-30
|
| Westend Sa |
1000000 |
2.25% |
-150000 |
-13.04% |
2020-06-30
|
| UBS Fund Management (Luxembourg) S.A. |
847700 |
2.24% |
269500 |
46.61% |
2020-07-31
|
| HHG PLC |
726931 |
1.92% |
726931 |
-- |
2020-03-31
|
| Consonance Capital Management LP |
1032636 |
2.73% |
103600 |
11.15% |
2020-03-31
|
| Fidelity Management & Research Company |
1736641 |
4.59% |
-24183 |
-1.37% |
2020-05-31
|
| Franklin Advisers, Inc. |
610570 |
1.61% |
67020 |
12.33% |
2019-12-31
|
| Franklin Resources Inc |
610570 |
1.61% |
67020 |
12.33% |
2019-12-31
|
| Partner Fund Management LP |
1158694 |
3.06% |
983940 |
563.04% |
2019-09-30
|
| Cormorant Asset Management, LLC |
900000 |
2.38% |
300000 |
50.00% |
2019-09-30
|
| Baker Bros Advisors LP |
517700 |
1.37% |
-- |
-- |
2019-12-31
|
| Federated Investors Inc |
1752893 |
4.63% |
480665 |
37.78% |
2019-06-30
|
| Susquehanna International Group, LLP |
871244 |
2.30% |
607987 |
230.95% |
2019-06-30
|
| Susquehanna Financial Group, LLLP |
871244 |
2.30% |
607987 |
230.95% |
2019-06-30
|
| Lord, Abbett & Co LLC |
584329 |
1.54% |
-63297 |
-9.77% |
2019-06-30
|
| OppenheimerFunds Inc |
1817534 |
4.80% |
90391 |
5.23% |
2019-03-31
|
| Eventide Asset Management, LLC |
538700 |
1.43% |
-197509 |
-26.83% |
2019-03-31
|
| OFI Global Asset Management, Inc. |
1332390 |
3.52% |
6045 |
0.46% |
2019-04-30
|
| Millennium Management LLC |
767098 |
2.03% |
283373 |
58.58% |
2018-12-31
|
| Forbion I Co II Management B V |
1865494 |
4.96% |
-- |
-- |
2017-12-31
|
| Fidelity International Ltd |
832012 |
2.21% |
-73011 |
-8.07% |
2018-09-30
|
| Perceptive Advisors LLC |
972831 |
2.61% |
-471797 |
-32.66% |
2018-09-30
|
| Federated Global Inv Mgmt Corp |
1565600 |
4.20% |
474320 |
43.46% |
2018-09-30
|
| Delaware Management Business Trust |
597000 |
1.60% |
-- |
-- |
2018-09-30
|
| Morgan Stanley & Co Inc |
670062 |
1.80% |
-54808 |
-7.56% |
2018-06-30
|
| ForUniQure B.V. |
4376883 |
13.78% |
4376883 |
-- |
2018-04-23
|
| Coller Investment Management Ltd |
2118520 |
6.88% |
99009 |
4.90% |
2017-12-14
|
| Parallax Volatility Advisers, LLC |
256269 |
0.69% |
256269 |
-- |
2018-06-30
|
| Franklin Advisers Inc |
243500 |
0.66% |
243500 |
-- |
2018-06-30
|
| Invesco PowerShares Capital Mgmt LLC |
176129 |
0.65% |
580 |
0.33% |
2018-08-30
|
| Fidelity Institutional Asset Management |
891000 |
2.80% |
-44400 |
-4.75% |
2018-03-31
|
| Jackson National Asset Management LLC |
191348 |
0.52% |
191348 |
-- |
2018-06-30
|
| Tekla Capital Management LLC |
199750 |
0.63% |
-133100 |
-39.99% |
2018-03-31
|
| PDT Partners, LLC |
135100 |
0.43% |
-3965 |
-2.85% |
2018-03-31
|
| Royce & Associates, LLC |
125000 |
0.40% |
125000 |
-- |
2017-12-31
|
| Foresite Capital Management II LLC |
109350 |
0.35% |
109350 |
-- |
2017-12-31
|
| Bogle Investment Management L P |
181378 |
0.58% |
181378 |
-- |
2017-12-31
|
| Two Sigma Investments LLC |
138891 |
0.44% |
138891 |
-- |
2017-12-31
|
| D. E. Shaw & Co LP |
106442 |
0.34% |
106442 |
-- |
2017-12-31
|
| Gilde Healthcare Holding BV |
1056946 |
4.18% |
-215943 |
-16.96% |
2016-12-31
|
| Forbion I Management BV |
1530501 |
6.06% |
-- |
-- |
2016-12-31
|
| SELECTRA MANAGEMENT COMPANY S.A. |
69509 |
0.23% |
-64493 |
-48.13% |
2018-02-28
|
| P.a.w. Capital Corp |
80000 |
0.26% |
-25000 |
-23.81% |
2017-12-31
|
| Deutsche Bank AG |
169056 |
0.66% |
18282 |
12.13% |
2017-09-30
|
| Renaissance Technologies Corp |
306700 |
1.20% |
-41400 |
-11.89% |
2017-09-30
|
| Dafna Capital Management LLC |
175307 |
0.68% |
-28600 |
-14.03% |
2017-09-30
|
| Spark Investment Management LLC |
161600 |
0.63% |
-98500 |
-37.87% |
2017-09-30
|
| Columbia Mangmt Investment Advisers, LLC |
68485 |
0.22% |
-- |
-- |
2017-12-31
|
| Mangrove Partners |
106634 |
0.42% |
66763 |
167.45% |
2017-09-30
|
| Merrill Lynch & Co Inc |
98176 |
0.38% |
-66400 |
-40.35% |
2017-09-30
|
| J.P. Morgan Securities Inc |
57563 |
0.22% |
-918 |
-1.57% |
2017-09-30
|
| Cooperatieve AAC LS U.A. |
987674 |
4.06% |
-- |
-- |
2015-12-31
|
| Close Finsbury Asset Management Limited |
489000 |
1.95% |
-- |
-- |
2016-10-31
|
| Putnam Investment Management,LLC |
340849 |
1.36% |
-33382 |
-8.92% |
2016-09-30
|
| UBS Group AG |
326600 |
1.30% |
-- |
-- |
2016-10-31
|
| 共同基金持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| Federated Hermes Kaufmann Growth |
580000 |
1.24% |
-66413 |
-10.27% |
2022-03-31
|
| Vanguard Extended Market Index Fund |
484844 |
1.04% |
-4030 |
-0.82% |
2022-05-31
|
| T. Rowe Price Health Sciences Fund |
216509 |
0.46% |
-99608 |
-31.51% |
2022-03-31
|
| Fidelity Advisor |
440000 |
0.94% |
-- |
-- |
2022-04-30
|
| Tekla Healthcare Investors |
357080 |
0.77% |
197016 |
123.09% |
2021-12-31
|
| Fidelity |
192257 |
0.41% |
-- |
-- |
2022-04-30
|
| iShares S&P Small-Cap 600 Growth ETF |
423509 |
0.91% |
-- |
-- |
2022-05-31
|
| Vanguard Tax Managed Small Cap Fund |
394699 |
0.85% |
50760 |
14.76% |
2022-05-31
|
| iShares Biotechnology ETF |
318401 |
0.68% |
-3514 |
-1.09% |
2022-05-31
|
| Avantis |
224775 |
0.48% |
4095 |
1.86% |
2022-05-31
|
| iShares Core S&P Small-Cap ETF |
2523706 |
5.41% |
3542 |
0.14% |
2022-05-31
|
| SPDR |
2319934 |
4.97% |
78430 |
3.50% |
2022-05-31
|
| JPM Thematics Genetic Therapies |
744889 |
1.60% |
-6990 |
-0.93% |
2022-05-31
|
| Delaware Healthcare Fund |
706166 |
1.51% |
-- |
-- |
2022-04-30
|
| Worldwide Healthcare |
613770 |
1.32% |
122596 |
24.96% |
2022-02-28
|
| Fidelity Growth Company Commingled Pool |
591877 |
1.27% |
-163328 |
-21.63% |
2022-04-30
|
| Federated Hermes Kaufmann |
580000 |
1.24% |
-66413 |
-10.27% |
2022-03-31
|
| BNY Mellon Sm/Md Cp Gr Fd |
312325 |
0.67% |
-3702 |
-1.17% |
2022-03-31
|
| JNL/Invesco Global Growth Fund |
206949 |
0.44% |
-781 |
-0.38% |
2021-12-31
|
| Invesco OFI Global Equity |
1031898 |
2.22% |
-- |
-- |
2021-12-31
|
| Federated Hermes Kaufmann Sm Cp Fd |
779869 |
1.68% |
-735131 |
-48.52% |
2021-12-31
|
| Federated Hermes Kaufmann Small Cap Grow |
779869 |
1.68% |
-735131 |
-48.52% |
2021-12-31
|
| T. Rowe Price New Horizons Fund |
451309 |
0.97% |
-106548 |
-19.10% |
2021-12-31
|
| Invesco Global Fund |
1031898 |
2.22% |
-- |
-- |
2022-01-31
|
| Pacer US Small Cap Cash Cows 100 ETF |
380736 |
0.82% |
7084 |
1.90% |
2022-02-28
|
| Invesco Large Cap Growth |
832625 |
1.80% |
-190385 |
-18.61% |
2021-06-30
|
| Invesco American Franchise Fund |
825974 |
1.79% |
-6651 |
-0.80% |
2021-07-31
|
| Janus Henderson US SMID Cap Growth |
634623 |
1.41% |
-- |
-- |
2020-12-31
|
| Janus Henderson Triton Fund |
634623 |
1.41% |
-- |
-- |
2020-12-31
|
| iShares Nasdaq Biotechnology ETF |
387925 |
0.87% |
1716 |
0.44% |
2021-01-28
|
| UBS (Lux) ES Long Term Themes (USD) |
384300 |
0.86% |
-- |
-- |
2020-09-30
|
| OFI Global Gbl Equity |
1031898 |
2.32% |
-- |
-- |
2020-09-30
|
| Eventide Healthcare & Life Sciences Fund |
500000 |
1.12% |
-- |
-- |
2020-06-30
|
| HBM Healthcare Investments AG |
400000 |
1.06% |
-- |
-- |
2020-03-31
|
| Franklin Innovation Composite |
400000 |
1.06% |
200000 |
100.00% |
2020-06-30
|
| Invesco Oppenheimer Global Fund |
1031898 |
2.73% |
-- |
-- |
2020-06-30
|
| Franklin DynaTech Fund |
400000 |
1.06% |
50000 |
14.29% |
2020-06-30
|
| Franklin DynaTech |
400000 |
1.06% |
50000 |
14.29% |
2020-06-30
|
| Federated Kaufmann Growth Equity |
1870000 |
4.94% |
-230000 |
-10.95% |
2020-03-31
|
| Federated Kaufmann Small Cap Growth |
934300 |
2.47% |
934300 |
-- |
2020-03-31
|
| Federated Kaufmann Fund |
1870000 |
4.94% |
-230000 |
-10.95% |
2020-03-31
|
| Federated Kaufmann Small Cap Fund |
934300 |
2.47% |
164300 |
21.34% |
2020-03-31
|
| T. Rowe Price QM US Small-Cap Gr Eq Fd |
296200 |
0.78% |
11700 |
4.11% |
2020-03-31
|
| Carillon Eagle Small Cap Growth Fund |
287115 |
0.76% |
-28341 |
-8.98% |
2020-03-31
|
| Franklin Biotechnology Discovery Fund |
246700 |
0.65% |
-- |
-- |
2020-03-31
|
| Fidelity Special Situations Fund |
296169 |
0.78% |
-- |
-- |
2019-06-30
|
| JNL/Oppenheimer Global Growth Fund |
244316 |
0.65% |
-- |
-- |
2019-12-31
|
| Lord Abbett Developing Growth Fund |
285732 |
0.75% |
-- |
-- |
2019-08-31
|
| Eventide Gilead Fund |
278700 |
0.74% |
-- |
-- |
2019-03-31
|
| Invesco Oppenheimer VI Global Fund |
204850 |
0.54% |
-3590 |
-1.72% |
2019-06-30
|
| Fidelity Global Innovators Cl |
214894 |
0.57% |
408 |
0.19% |
2018-09-30
|
| Oppenheimer Global Fund |
853620 |
2.26% |
-- |
-- |
2019-03-31
|
| Oppenheimer Global Fund/VA |
182420 |
0.48% |
-- |
-- |
2019-02-28
|
| LSP Life Sciences Fund N.V. |
158339 |
0.42% |
39539 |
33.28% |
2019-01-31
|
| Fidelity Special Situations Class |
576394 |
1.55% |
-- |
-- |
2018-09-30
|
| Oppenheimer Main Street All Cap Fund |
110780 |
0.30% |
-- |
-- |
2018-10-31
|
| Lupus alpha Fds Lupus alpha Micro Champ |
159900 |
0.43% |
99900 |
166.50% |
2017-12-31
|
| Federated Kaufmann R |
852471 |
2.30% |
149536 |
21.27% |
2018-06-30
|
| Oppenheimer Global A |
727890 |
1.96% |
5910 |
0.82% |
2018-07-31
|
| Delaware Healthcare A |
597000 |
1.61% |
-- |
-- |
2018-07-31
|
| Eventide Healthcare & Life Sciences A |
475350 |
1.28% |
140350 |
41.90% |
2018-06-30
|
| iShares Nasdaq Biotechnology |
410690 |
1.09% |
-783 |
-0.19% |
2018-09-12
|
| Eventide Gilead N |
278700 |
0.75% |
278700 |
-- |
2018-06-30
|
| Federated Kaufmann Small Cap A |
216760 |
0.58% |
19840 |
10.08% |
2018-06-30
|
| JNL/Oppenheimer Global Growth B |
174730 |
0.47% |
174730 |
-- |
2018-06-30
|
| Oppenheimer Global VA Svc |
169110 |
0.46% |
-560 |
-0.33% |
2018-07-31
|
| PowerShares DWA Healthcare Momentum ETF |
100553 |
0.26% |
-- |
-- |
2018-09-13
|
| VY Oppenheimer Global I |
108100 |
0.29% |
108100 |
-- |
2018-06-30
|
| Royce Smaller-Companies Growth Svc |
100000 |
0.27% |
-25000 |
-20.00% |
2018-06-30
|
| PowerShares DWA SmallCap Momentum ETF |
90429 |
0.24% |
-- |
-- |
2018-09-13
|
| Oppenheimer Main Street Select A |
110780 |
0.30% |
-- |
-- |
2018-07-31
|
| Met Invt Ser Oppenheimer Glbl Eq B |
90510 |
0.24% |
90510 |
-- |
2018-06-30
|
| Oppenheimer Main Street Small Cap VA Svc |
94020 |
0.25% |
-- |
-- |
2018-06-30
|
| Franklin Biotechnology Discovery A |
84700 |
0.23% |
-- |
-- |
2018-06-30
|
| Columbia VP US Equities 2 |
69150 |
0.19% |
18050 |
35.32% |
2018-06-30
|
| Fidelity VIP Health Care Inv |
71206 |
0.19% |
6085 |
9.34% |
2018-05-31
|
| Oppenheimer Main Street Small Cap A |
52258 |
0.14% |
52258 |
-- |
2018-05-31
|
| Vanguard Health Care ETF |
50769 |
0.14% |
2846 |
5.94% |
2018-05-31
|
| Tekla Life Sciences Investors |
75482 |
0.24% |
2853 |
3.93% |
2018-03-31
|
| Strategic Advisers |
60000 |
0.19% |
-- |
-- |
2018-04-30
|
| iShares Micro-Cap |
60071 |
0.18% |
-- |
-- |
2018-06-21
|
| BioShares |
43456 |
0.12% |
-- |
-- |
2018-06-14
|
| Columbia Small Cap Growth I Z |
47700 |
0.15% |
-- |
-- |
2018-03-31
|
| Bogle Small Cap Growth Instl |
45921 |
0.15% |
-16637 |
-26.59% |
2018-02-28
|
| RS Technology A |
35040 |
0.11% |
35040 |
-- |
2017-12-31
|
| Fidelity Asset Manager |
24862 |
0.08% |
24862 |
-- |
2017-12-31
|
| AXA/Lord Abbett Micro Cap K |
3056 |
0.01% |
-- |
-- |
2017-10-31
|
| Putnam Global Health Care A |
258886 |
1.03% |
-7797 |
-2.92% |
2016-12-31
|
| Boston Partners Long/Short Equity Instl |
233262 |
0.93% |
233262 |
-- |
2016-12-31
|
| TFS Market Neutral |
35216 |
0.14% |
1465 |
4.34% |
2016-10-31
|
| Putnam VT Global Health Care IA |
26675 |
0.11% |
-803 |
-2.92% |
2016-12-31
|
| Putnam Capital Opportunities A |
17576 |
0.07% |
-5100 |
-22.49% |
2016-12-31
|
| Putnam Small Cap Growth A |
15124 |
0.06% |
200 |
1.34% |
2016-12-31
|
| Voya Multi-Manager International Sm Cp A |
10205 |
0.04% |
10205 |
-- |
2016-12-31
|
| Great-West Multi-Manager Sm Cp Gr Instl |
2271 |
0.01% |
-- |
-- |
2016-11-30
|
| Putnam VT Capital Opportunities IB |
1785 |
0.01% |
-- |
-- |
2016-12-31
|
| Weiss Alternative Balanced Risk I |
18 |
-- |
3 |
20.00% |
2016-12-31
|
| Oppenheimer International Small Co Fund |
158720 |
0.70% |
-- |
-- |
2015-09-30
|
| DWS Biotech |
40000 |
0.20% |
-- |
-- |
2015-09-30
|
| Tocqueville Opportunity |
35500 |
0.20% |
3500 |
10.90% |
2015-09-30
|
