| 开盘价:-- |
最高价:-- |
最低价:-- |
52周最高价:-- |
52周最低价:-- |
| 成交量:-- |
平均成交量:-- |
市值:-- |
市盈率:-- |
预期市盈率:-- |
| 每股收益:-- |
贝塔系数:-- |
股息:-- |
收益率:-- |
总股本:-- |
| 机构持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| BlackRock Inc |
4150231 |
11.77% |
141160 |
3.52% |
2021-12-31
|
| Vanguard Group Inc |
3252411 |
9.22% |
67233 |
2.11% |
2022-03-31
|
| T. Rowe Price Associates, Inc. |
3093259 |
8.77% |
764728 |
32.84% |
2022-03-31
|
| Jackson Square Partners, LLC |
2443095 |
6.93% |
-9402 |
-0.38% |
2021-12-31
|
| BlackRock Fund Advisors |
1601536 |
4.54% |
18717 |
1.18% |
2022-05-31
|
| Wellington Management Company LLP |
1509224 |
4.28% |
842951 |
126.52% |
2021-12-31
|
| Fidelity SelectCo, LLC |
1312190 |
3.72% |
-99550 |
-7.05% |
2022-05-31
|
| Hartford Funds Management Company, LLC |
1270828 |
3.60% |
279122 |
28.15% |
2022-05-31
|
| JPMorgan Chase & Co |
1176299 |
3.34% |
747 |
0.06% |
2021-12-31
|
| Amvescap Plc. |
1034650 |
2.93% |
-375592 |
-26.63% |
2021-12-31
|
| J.P. Morgan Investment Management, Inc. |
1028821 |
2.92% |
-7259 |
-0.70% |
2022-05-31
|
| Vanguard Investments Australia Ltd |
979908 |
2.78% |
1342 |
0.14% |
2022-05-31
|
| Franklin Resources Inc |
911357 |
2.58% |
-2559 |
-0.28% |
2021-12-31
|
| FMR Inc |
909742 |
2.58% |
-406007 |
-30.86% |
2021-12-31
|
| Fred Alger Management, LLC |
898602 |
2.55% |
-314119 |
-25.90% |
2021-12-31
|
| Franklin Advisers, Inc. |
889001 |
2.52% |
-105226 |
-10.58% |
2021-12-31
|
| ArrowMark Colorado Holdings, LLC (ArrowMark Partners) |
855439 |
2.43% |
113107 |
15.24% |
2022-03-31
|
| State Street Corporation |
804431 |
2.28% |
29882 |
3.86% |
2022-03-31
|
| Capital Research Global Investors |
1582704 |
4.49% |
213670 |
15.61% |
2021-12-31
|
| Fidelity Management & Research Company LLC |
941357 |
2.67% |
-752680 |
-44.43% |
2022-04-30
|
| Alger Associates, Inc. |
2136612 |
6.07% |
222654 |
11.63% |
2020-12-31
|
| Capital Research and Management Company |
1925374 |
5.49% |
92496 |
5.05% |
2022-03-31
|
| BlackRock Advisors LLC |
1077506 |
3.07% |
195780 |
22.20% |
2022-02-28
|
| Rock Springs Capital Management LP |
635700 |
1.82% |
104700 |
19.72% |
2021-09-30
|
| Perceptive Advisors LLC |
1637520 |
4.70% |
825366 |
101.63% |
2021-06-30
|
| Fidelity Management and Research Company |
1899812 |
5.45% |
500492 |
35.77% |
2021-03-31
|
| D. E. Shaw & Co LP |
1099450 |
3.16% |
-157327 |
-12.52% |
2020-12-31
|
| D E Shaw & Co , LP |
1932518 |
5.58% |
1932518 |
-- |
2019-12-31
|
| D.e. Shaw & Co., L.p. |
2116224 |
6.15% |
2116224 |
-- |
2019-11-07
|
| D.e. Shaw & Co., L.p. |
2116224 |
6.15% |
2116224 |
-- |
2019-11-07
|
| D E Shaw & Co , LP |
1932518 |
5.61% |
1932518 |
-- |
2019-12-31
|
| Fidelity Management & Research Company LLC |
1611845 |
4.68% |
-80195 |
-4.74% |
2020-11-30
|
| D. E. Shaw & Co LP |
1256777 |
3.65% |
-4477 |
-0.35% |
2020-09-30
|
| JPMorgan Chase & Co |
992382 |
2.88% |
-133428 |
-11.85% |
2020-06-30
|
| Healthcor Management LP |
1054103 |
3.06% |
-698517 |
-39.86% |
2020-06-30
|
| T Rowe Price Associates, Inc |
3078614 |
8.97% |
3078614 |
-- |
2019-05-31
|
| Victory Capital Management Inc. |
806544 |
2.61% |
411313 |
104.07% |
2020-03-31
|
| Fidelity Management & Research Company |
933700 |
3.02% |
401485 |
75.44% |
2020-05-31
|
| Redmile Group, LLC |
706426 |
2.29% |
-232738 |
-24.78% |
2020-03-31
|
| Citadel Advisors Llc |
623589 |
2.02% |
-187013 |
-23.07% |
2019-12-31
|
| Geode Capital Management, LLC |
811464 |
2.63% |
432396 |
114.07% |
2019-12-31
|
| Northern Trust Investments Inc |
598031 |
1.94% |
-6140 |
-1.02% |
2020-04-30
|
| T. Rowe Price |
662184 |
2.14% |
205307 |
44.94% |
2020-04-30
|
| Lord, Abbett & Co LLC |
593952 |
1.92% |
-114428 |
-16.15% |
2019-12-31
|
| Partner Fund Management LP |
577163 |
1.87% |
180893 |
45.65% |
2019-12-31
|
| JP Morgan Asset Management (UK) Ltd |
555093 |
1.80% |
15694 |
2.91% |
2019-06-30
|
| OppenheimerFunds Inc |
1500000 |
4.86% |
-- |
-- |
2019-03-31
|
| Fred Alger Management Inc |
1036977 |
3.36% |
69801 |
7.22% |
2019-06-30
|
| Invesco Ltd (OFI / OppenheimerFunds) |
1500000 |
4.86% |
-- |
-- |
2019-08-31
|
| Millennium Management LLC |
1110912 |
3.60% |
-30167 |
-2.64% |
2019-03-31
|
| Credit Suisse First Boston (CSFB) |
548345 |
1.78% |
1806 |
0.33% |
2019-06-30
|
| Adage Capital Partners Gp LLC |
700000 |
2.29% |
592500 |
551.16% |
2019-03-31
|
| Broadfin Capital, LLC |
622615 |
2.04% |
-121800 |
-16.36% |
2019-03-31
|
| Vanguard |
601301 |
1.97% |
-97156 |
-13.91% |
2019-07-31
|
| Deerfield Management Co |
579463 |
1.90% |
-334810 |
-36.62% |
2019-03-31
|
| BlackRock Asset Management Canada Ltd |
679355 |
2.23% |
-207 |
-0.03% |
2019-05-31
|
| Bank of America Corporation |
895716 |
2.93% |
696721 |
350.12% |
2018-12-31
|
| OFI Global Asset Management, Inc. |
1500000 |
4.91% |
-725 |
-0.05% |
2019-04-30
|
| Point72 Asset Management, L.P. |
1318707 |
4.34% |
-171935 |
-11.53% |
2018-12-31
|
| Orbimed Advisors, LLC |
1357691 |
4.47% |
97600 |
7.75% |
2018-09-30
|
| Zevenbergen Capital Investments LLC |
673480 |
2.22% |
5750 |
0.86% |
2018-09-30
|
| Consonance Capital Management LP |
1446333 |
4.76% |
503263 |
53.36% |
2018-09-30
|
| Jennison Associates LLC |
1501045 |
4.98% |
-189720 |
-11.22% |
2018-09-30
|
| HHG PLC |
1241720 |
4.12% |
-643835 |
-34.15% |
2018-09-30
|
| Janus Capital Management LLC |
910830 |
3.02% |
-386496 |
-29.79% |
2018-12-31
|
| PGIM Investments LLC |
965810 |
3.20% |
383 |
0.04% |
2018-11-30
|
| Wells Fargo Funds Management LLC |
898931 |
2.98% |
-105676 |
-10.52% |
2018-11-30
|
| BlackRock Institutional Trust Company NA |
810645 |
2.69% |
62932 |
8.42% |
2018-06-30
|
| Wells Capital Management Inc. |
1317188 |
4.37% |
557101 |
73.29% |
2018-06-30
|
| Goldman Sachs Group Inc |
749756 |
2.49% |
-164415 |
-17.99% |
2018-06-30
|
| Wells Fargo & Co |
1366980 |
4.53% |
543401 |
65.98% |
2018-06-30
|
| AllianceBernstein L.P. |
1316588 |
4.37% |
-205460 |
-13.50% |
2018-06-30
|
| Franklin Advisers Inc |
1733338 |
5.76% |
181827 |
11.72% |
2018-06-30
|
| AllianceBernstein LP |
1316588 |
4.37% |
-205460 |
-13.50% |
2018-06-30
|
| Arrowpoint Asset Management, LLC |
945992 |
3.14% |
183193 |
24.02% |
2018-06-30
|
| State Street Corp |
645622 |
2.15% |
61300 |
10.49% |
2018-06-30
|
| Goldman Sachs Asset Management LP |
644897 |
2.14% |
-201292 |
-23.79% |
2018-06-30
|
| Invesco Advisers, Inc |
611650 |
2.03% |
-7172 |
-1.16% |
2018-06-30
|
| Artisan Partners Limited Partnership |
596939 |
1.98% |
9152 |
1.56% |
2018-06-30
|
| Kornitzer Capital Management Inc |
578841 |
1.92% |
-41972 |
-6.76% |
2018-06-30
|
| J P Morgan Asset Management (UK) Ltd |
511803 |
1.71% |
6724 |
1.33% |
2018-03-31
|
| Frontier Capital Management CO Inc |
831786 |
2.78% |
-55616 |
-6.27% |
2018-03-31
|
| Prudential Investments LLC |
1062264 |
3.54% |
216605 |
25.61% |
2018-05-31
|
| Deutsche Bank AG |
724086 |
2.43% |
-395093 |
-35.30% |
2017-12-31
|
| Tourbillon Capital Partners LP |
585000 |
1.97% |
190000 |
48.10% |
2017-12-31
|
| Johnson & Johnson |
1400824 |
4.85% |
-665916 |
-32.22% |
2016-12-31
|
| THREE ARCH PARTNERS IV LP |
1168321 |
4.04% |
1168321 |
-- |
2016-12-31
|
| NEA Management Company, LLC |
660428 |
2.31% |
-- |
-- |
2016-09-30
|
| 1832 Asset Management L.P |
614300 |
2.15% |
539300 |
719.07% |
2016-09-30
|
| Bay City Capital LLC |
700000 |
2.46% |
-1517214 |
-68.43% |
2016-08-09
|
| Cormorant Asset Management, LLC |
491044 |
1.72% |
-- |
-- |
2016-09-30
|
| Oak Ridge Investments, LLC |
472940 |
1.65% |
-60424 |
-11.33% |
2016-09-30
|
| American Century Inv Mgt Inc |
438436 |
1.53% |
195252 |
80.29% |
2016-09-30
|
| Johnson Johnson Development Corporation |
3077005 |
3.00% |
150034764 |
0.10% |
1999-11-30
|
| Nathan B. Pliam, M.D |
2217214 |
3.00% |
108111355 |
0.10% |
1999-11-30
|
| Wilfred E. Jaeger, M.D. |
2210569 |
3.00% |
107787344 |
0.10% |
1999-11-30
|
| Novo A/S |
2194841 |
3.00% |
107020447 |
0.10% |
1999-11-30
|
| AMV Partners II, L.P. |
1685340 |
3.00% |
82177178 |
0.10% |
1999-11-30
|
| Entities affiliated with Aberdare Ventures |
1615273 |
3.00% |
78760711 |
0.10% |
1999-11-30
|
| Ali Behbahani, M.D. |
1367649 |
3.00% |
66686565 |
-- |
1999-11-30
|
| 共同基金持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| BlackRock Health Sciences Trust II |
511890 |
1.45% |
66765 |
15.00% |
2022-03-31
|
| Vanguard Small Cap Growth Index Fund |
504047 |
1.43% |
-194 |
-0.04% |
2022-04-30
|
| Alger Weatherbie Specialized Growth Fund |
328653 |
0.93% |
-7470 |
-2.22% |
2022-03-31
|
| Vanguard Extended Market Index Fund |
461499 |
1.31% |
-861 |
-0.19% |
2022-04-30
|
| Franklin US Opportunities Fund |
376116 |
1.07% |
-- |
-- |
2022-04-30
|
| iShares Russell 2000 Growth ETF |
299772 |
0.85% |
-345 |
-0.11% |
2022-05-31
|
| JPMorgan Small Cap Growth Fund |
427134 |
1.21% |
-3064 |
-0.71% |
2022-04-30
|
| Franklin U.S. Opportunities Composite |
376116 |
1.07% |
-- |
-- |
2022-03-31
|
| JPM Global Healthcare Fund |
375264 |
1.06% |
-5788 |
-1.52% |
2022-04-30
|
| Vanguard Explorer Fund |
344215 |
0.98% |
74483 |
27.61% |
2022-03-31
|
| T. Rowe Price New Horizons Fund |
1577855 |
4.47% |
632990 |
66.99% |
2022-03-31
|
| Fidelity |
1280000 |
3.63% |
-- |
-- |
2022-04-30
|
| Invesco Global Opportunities Fund |
1000000 |
2.84% |
-- |
-- |
2022-04-30
|
| Invesco Global Multi Cap Growth |
1000000 |
2.84% |
-- |
-- |
2022-03-31
|
| Vanguard Total Stock Market Index Fund |
973916 |
2.76% |
1559 |
0.16% |
2022-04-30
|
| Vanguard Small Cap Index |
835665 |
2.37% |
1762 |
0.21% |
2022-04-30
|
| iShares Russell 2000 ETF |
782458 |
2.22% |
1330 |
0.17% |
2022-05-31
|
| BlackRock Health Sciences Opps Port |
695930 |
1.97% |
-- |
-- |
2022-03-31
|
| BGF World Healthscience Fund |
620576 |
1.76% |
36139 |
6.18% |
2022-02-28
|
| Hartford MidCap Fund |
619037 |
1.76% |
-45200 |
-6.80% |
2022-04-30
|
| Franklin Small Cap Growth Fund |
282700 |
0.80% |
78400 |
38.37% |
2022-03-31
|
| Franklin US Small Cap Growth Equity |
282700 |
0.80% |
78400 |
38.37% |
2022-03-31
|
| American Funds SMALLCAP World Fund |
1612464 |
4.60% |
271000 |
20.20% |
2021-12-31
|
| Jackson Square SMID Cap Growth CIT |
402398 |
1.15% |
24597 |
6.51% |
2021-12-31
|
| Jackson Square SMID-Cap Growth Fund |
548952 |
1.57% |
-135602 |
-19.81% |
2022-01-31
|
| Jackson Square SMID-Cap Gro CIT Fd |
402398 |
1.15% |
24597 |
6.51% |
2021-12-31
|
| T. Rowe Price Small-Cap Stock Fund |
298944 |
0.86% |
49400 |
19.80% |
2021-09-30
|
| T. Rowe Price New Horizons Trust |
344060 |
0.99% |
-15700 |
-4.36% |
2021-09-30
|
| CREF Stock Account |
282561 |
0.81% |
13023 |
4.83% |
2021-08-31
|
| Alger Small Cap Focus Fund |
954833 |
2.74% |
-- |
-- |
2021-07-31
|
| Alger Small Cap Focus |
954833 |
2.74% |
-- |
-- |
2021-07-31
|
| Credit Suisse (Lux) Digital Health Eq Fd |
360000 |
1.03% |
-- |
-- |
2020-12-31
|
| T. Rowe Price Health Sciences Fund |
319160 |
0.92% |
-85614 |
-21.15% |
2021-06-30
|
| Franklin Growth Opportunities Fund |
279993 |
0.81% |
-- |
-- |
2021-05-31
|
| Lord Abbett & Co. Growth Equity |
389118 |
1.12% |
-10658 |
-2.67% |
2020-12-31
|
| Lord Abbett Growth Leaders Fund |
389118 |
1.12% |
-- |
-- |
2021-01-31
|
| Invesco Global Opports Fund |
1000000 |
2.89% |
-- |
-- |
2020-12-31
|
| OFI Global Global Multi Cap Growth |
1000000 |
2.90% |
-- |
-- |
2020-09-30
|
| Lord Abbett & Co. Growth Equity |
399776 |
1.16% |
99520 |
33.15% |
2020-09-30
|
| Invesco Oppenheimer Global Opports Fund |
1000000 |
2.91% |
-- |
-- |
2020-06-30
|
| Victory RS Small Cap Growth Fund |
240010 |
0.78% |
3200 |
1.35% |
2020-03-31
|
| Victory RS Small Cap Growth CIT |
240010 |
0.78% |
3200 |
1.35% |
2020-03-31
|
| Lord Abbett Developing Growth Fund |
321981 |
1.04% |
-2947 |
-0.91% |
2019-12-31
|
| BNY Mellon Sm/Md Cp Gr Fd |
291353 |
0.94% |
-6802 |
-2.28% |
2019-09-30
|
| Meridian Growth Fund |
347345 |
1.12% |
-- |
-- |
2019-03-31
|
| Alger SMid Cap Focus Fund |
324301 |
1.05% |
10541 |
3.36% |
2019-07-31
|
| Franklin Technology Fund |
293800 |
0.95% |
-- |
-- |
2019-07-31
|
| Meridian Small Cap Growth Fund |
317790 |
1.04% |
-- |
-- |
2019-03-31
|
| iShares US Small Cap ETF (CAD-Hedged) |
593785 |
1.95% |
-999 |
-0.17% |
2019-05-30
|
| Vanguard Small Cap Index Fund |
714655 |
2.34% |
5580 |
0.79% |
2019-04-30
|
| Oppenheimer Global Opportunities Fund |
1500000 |
4.91% |
-- |
-- |
2019-03-31
|
| Federated Kaufmann Fund |
360294 |
1.18% |
-- |
-- |
2018-12-31
|
| SPDR |
230952 |
0.76% |
1511 |
0.66% |
2019-04-26
|
| SEB Life Intl E-Fund |
293800 |
0.97% |
-- |
-- |
2019-02-28
|
| ILI Franklin US Opportunities EUR |
548618 |
1.81% |
-- |
-- |
2019-02-28
|
| iShares US Medical Devices ETF |
309063 |
1.02% |
1058 |
0.34% |
2019-02-28
|
| Dreyfus/The Boston Co Sm/Md Cp Gr Fd |
246016 |
0.81% |
8527 |
3.59% |
2019-01-31
|
| PGIM Jennison Health Sciences Fund |
300385 |
0.99% |
-- |
-- |
2019-01-31
|
| ZI Franklin US Opportunities |
548618 |
1.81% |
67787 |
14.10% |
2019-01-31
|
| JPM Global Healthcare Fund UL |
339220 |
1.12% |
7348 |
2.21% |
2019-01-31
|
| FPIL Optus JF Glb Life Sciences Theme |
339220 |
1.12% |
7348 |
2.21% |
2019-01-31
|
| Buffalo Discovery Fund |
247415 |
0.81% |
-101600 |
-29.11% |
2018-09-30
|
| Worldwide Healthcare |
389500 |
1.29% |
-53700 |
-12.12% |
2018-10-31
|
| Janus Henderson Triton Fund |
686722 |
2.28% |
-265042 |
-27.85% |
2018-09-30
|
| PGIM Jennison Small Company Fund |
396684 |
1.32% |
-- |
-- |
2018-10-31
|
| Wells Fargo Growth Fund |
394163 |
1.31% |
41600 |
11.80% |
2018-06-30
|
| AZ InvestEd Ivy Small Cap Growth Fund |
346837 |
1.15% |
31100 |
9.85% |
2018-06-30
|
| Wells Fargo Discovery Fund |
300100 |
1.00% |
-- |
-- |
2018-06-30
|
| Goldman Sachs Small/Mid Cap Growth Fund |
345922 |
1.15% |
-- |
-- |
2018-06-30
|
| Janus Triton D |
951764 |
3.16% |
-- |
-- |
2018-06-30
|
| Oppenheimer Global Opportunities A |
900000 |
2.99% |
-- |
-- |
2018-07-31
|
| Vanguard Total Stock Mkt Idx |
675091 |
2.24% |
828 |
0.12% |
2018-07-31
|
| Franklin Small Cap Growth A |
582700 |
1.93% |
49900 |
9.37% |
2018-07-31
|
| Prudential Jennison Health Sciences A |
536744 |
1.78% |
9536 |
1.81% |
2018-07-31
|
| Buffalo Discovery |
349015 |
1.16% |
-64800 |
-15.66% |
2018-06-30
|
| AZ InvestEd Ivy Small Cap Growth E |
346837 |
1.15% |
31100 |
9.85% |
2018-06-30
|
| Goldman Sachs Small/Mid Cap Growth A |
345922 |
1.15% |
-- |
-- |
2018-06-30
|
| Janus Global Life Sciences D |
345562 |
1.15% |
-62654 |
-15.35% |
2018-06-30
|
| BlackRock Health Sciences Opps Inv A |
451200 |
1.50% |
-- |
-- |
2018-07-31
|
| Prudential Jennison Small Company B |
396684 |
1.32% |
-107021 |
-21.25% |
2018-07-31
|
| Vanguard Small Cap Growth Index Inv |
388350 |
1.29% |
5342 |
1.39% |
2018-07-31
|
| Franklin Growth Opportunities A |
384397 |
1.28% |
60656 |
18.74% |
2018-07-31
|
| Vanguard Extended Market Idx Inv |
372284 |
1.24% |
3000 |
0.81% |
2018-07-31
|
| Artisan Small Cap Investor |
249538 |
0.83% |
8687 |
3.61% |
2018-06-30
|
| iShares Russell 2000 Growth |
280059 |
0.86% |
-270 |
-0.10% |
2018-09-12
|
| Federated Kaufmann R |
215000 |
0.71% |
-25000 |
-10.42% |
2018-06-30
|
| Vanguard Explorer Inv |
213671 |
0.71% |
32498 |
17.94% |
2018-06-30
|
| JPMorgan Small Cap Growth A |
302707 |
1.01% |
22798 |
8.14% |
2018-07-31
|
| Wells Fargo Growth A |
394163 |
1.31% |
41600 |
11.80% |
2018-06-30
|
| Wells Fargo Discovery Admin |
300100 |
1.00% |
-- |
-- |
2018-06-30
|
| Wells Fargo Small Company Growth Admin |
267637 |
0.89% |
15556 |
6.17% |
2018-06-30
|
| RI CBF AllianceBern Discovery Gr RA |
268842 |
0.89% |
-23500 |
-8.04% |
2018-06-30
|
| Goldman Sachs Growth Opportunities A |
254199 |
0.85% |
-26030 |
-9.29% |
2018-03-31
|
| Lord Abbett Developing Growth A |
295037 |
0.98% |
46590 |
18.75% |
2018-04-30
|
| AB Small Cap Growth A |
208445 |
0.70% |
-310 |
-0.15% |
2018-02-28
|
| Invesco Small Cap Growth A |
210931 |
0.71% |
326 |
0.15% |
2017-09-30
|
| Franklin Small-Mid Cap Growth A |
221500 |
0.75% |
-- |
-- |
2017-09-30
|
| American Century Heritage Inv |
433118 |
1.51% |
130152 |
42.96% |
2016-12-31
|
| Buffalo Small Cap |
222863 |
0.78% |
-71150 |
-24.20% |
2016-09-30
|
| Oak Ridge Small Cap Growth A |
285000 |
0.99% |
-65000 |
-18.57% |
2016-11-30
|
