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Alpine Immune Sciences, Inc. (alpn)
| 开盘价:-- |
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最低价:-- |
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52周最低价:-- |
| 成交量:-- |
平均成交量:-- |
市值:-- |
市盈率:-- |
预期市盈率:-- |
| 每股收益:-- |
贝塔系数:-- |
股息:-- |
收益率:-- |
总股本:-- |
| 机构持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| Bridgeway Capital Management, LLC |
145611 |
0.48% |
-- |
-- |
2022-03-31
|
| Omega Fund Management LLC |
2029580 |
6.69% |
-- |
-- |
2022-03-31
|
| FRAZIER MANAGEMENT LLC |
1784913 |
5.89% |
13069 |
0.74% |
2021-12-31
|
| Bvf Inc |
1589495 |
5.24% |
-- |
-- |
2022-03-31
|
| Lynx1 Capital Management LP |
1537345 |
5.07% |
1537345 |
-- |
2022-04-14
|
| Avidity Partners Management LP |
1207000 |
3.98% |
-138000 |
-10.26% |
2022-03-31
|
| TCG Crossover Management, LLC |
1034222 |
3.41% |
-135990 |
-11.62% |
2022-03-31
|
| BlackRock Inc |
728848 |
2.40% |
181066 |
33.05% |
2021-12-31
|
| Vanguard Group Inc |
707598 |
2.33% |
9844 |
1.41% |
2022-03-31
|
| Artal Group S A |
593030 |
1.96% |
-- |
-- |
2022-03-31
|
| BlackRock Fund Advisors |
480838 |
1.59% |
-8610 |
-1.76% |
2022-05-31
|
| Vanguard Investments Australia Ltd |
458029 |
1.51% |
-- |
-- |
2022-05-31
|
| Renaissance Technologies Corp |
386094 |
1.27% |
-200 |
-0.05% |
2022-03-31
|
| Paradigm Biocapital Advisors LP |
336229 |
1.11% |
336229 |
-- |
2022-03-31
|
| State Street Corporation |
220621 |
0.73% |
14609 |
7.09% |
2022-03-31
|
| Geode Capital Management, LLC |
215156 |
0.71% |
18490 |
9.40% |
2022-03-31
|
| Fidelity Management & Research Company LLC |
209118 |
0.69% |
-1143 |
-0.54% |
2022-05-31
|
| Northern Trust Investments Inc |
170161 |
0.56% |
-5030 |
-2.87% |
2022-05-31
|
| Orbimed Advisors, LLC |
4081592 |
13.46% |
-- |
-- |
2022-03-31
|
| Logos Global Management LP |
1120000 |
3.69% |
695000 |
163.53% |
2021-12-31
|
| Longwood Capital Partners LLC |
230000 |
0.76% |
230000 |
-- |
2021-12-31
|
| Tiger Management Llc/ny |
137728 |
0.47% |
-- |
-- |
2021-12-31
|
| Northern Trust Corp |
107234 |
0.37% |
-6345 |
-5.59% |
2021-09-30
|
| State Street Global Advisors |
126767 |
0.43% |
1983 |
1.59% |
2022-02-28
|
| Dafna Capital Management LLC |
111501 |
0.38% |
-1801 |
-1.59% |
2021-09-30
|
| Deutsche Bank AG |
134057 |
0.46% |
-110275 |
-45.13% |
2021-06-30
|
| Samsara BioCapital, LLC |
275169 |
0.94% |
-124021 |
-31.07% |
2021-06-30
|
| Ikarian Capital, LLC |
300454 |
1.03% |
-4285 |
-1.41% |
2021-06-30
|
| EcoR1 Capital, LLC |
522635 |
1.79% |
-218655 |
-29.50% |
2021-06-30
|
| Frazier Life Sciences VIII, L.P. |
2571450 |
8.81% |
-145251 |
-5.35% |
2020-07-28
|
| Westend Sa |
593030 |
2.03% |
-- |
-- |
2021-03-31
|
| DWS Investments UK Limited |
244332 |
0.84% |
244332 |
-- |
2021-03-31
|
| Sphera Funds Management Ltd. |
198260 |
0.83% |
-- |
-- |
2021-03-31
|
| Opaleye Management Inc |
156500 |
0.65% |
156500 |
-- |
2021-03-31
|
| Soleus Capital Management, L.P. |
313064 |
1.31% |
272000 |
662.38% |
2021-03-31
|
| PURA VIDA INVESTMENTS, LLC |
131981 |
0.55% |
-5127 |
-3.74% |
2021-03-31
|
| Farallon Capital Management, L.L.C. |
200000 |
0.84% |
-541290 |
-73.02% |
2020-12-31
|
| Morgan Stanley - Brokerage Accounts |
377723 |
1.58% |
375306 |
15527.76% |
2020-12-31
|
| CAAS CAPITAL MANAGEMENT LP |
148200 |
0.62% |
148200 |
-- |
2020-12-31
|
| Two Sigma Investments LLC |
148443 |
0.62% |
67078 |
82.44% |
2020-12-31
|
| Two Sigma Advisers, LLC |
73475 |
0.31% |
73475 |
-- |
2020-09-30
|
| Dimensional Fund Advisors LP |
54292 |
0.23% |
-5443 |
-9.11% |
2020-12-31
|
| Dimensional Fund Advisors, Inc. |
48154 |
0.20% |
7600 |
18.74% |
2020-09-30
|
| Berman Capital Advisors, LLC |
54524 |
0.23% |
54524 |
-- |
2020-06-30
|
| Hikari Power Ltd |
50445 |
0.21% |
-117143 |
-69.90% |
2020-06-30
|
| Fidelity Management & Research Company LLC |
57189 |
0.24% |
6618 |
13.09% |
2020-11-30
|
| Hancock Whitney Corp |
10400 |
0.04% |
-- |
-- |
2020-10-31
|
| Horizon Advisers |
10400 |
0.04% |
-- |
-- |
2020-10-31
|
| Pathstone Family Office, LLC |
10010 |
0.04% |
10010 |
-- |
2020-06-30
|
| Leonard Rickey Investment Advisors, P.L.L.C. |
10000 |
0.04% |
-- |
-- |
2020-06-30
|
| SEI Investments Management Corp |
67545 |
0.28% |
-161246 |
-70.48% |
2020-09-30
|
| Northern Trust Asset Management |
4867 |
0.02% |
-977 |
-16.72% |
2020-08-31
|
| Royal Bank of Canada |
8353 |
0.04% |
3002 |
56.10% |
2020-06-30
|
| Alpine Woods Capital Investors, LLC |
10580 |
0.04% |
-- |
-- |
2020-03-31
|
| Northern Trust Investments N A |
10188 |
0.04% |
-- |
-- |
2020-03-31
|
| Vericimetry Advisors LLC |
9900 |
0.05% |
9900 |
-- |
2020-05-31
|
| Fidelity Management & Research Company |
44320 |
0.24% |
-- |
-- |
2020-05-31
|
| DRW Securities, LLC |
10000 |
0.05% |
-- |
-- |
2019-12-31
|
| Deerfield Management Co |
248992 |
1.34% |
-157934 |
-38.81% |
2019-12-31
|
| Victory Capital Management Inc. |
132603 |
0.71% |
1581 |
1.21% |
2019-09-30
|
| Raymond James & Associates |
15641 |
0.08% |
1897 |
13.80% |
2019-06-30
|
| Jacobs Levy Equity Management, Inc. |
21274 |
0.11% |
21274 |
-- |
2019-06-30
|
| Bridgeway Capital Management, Inc |
35750 |
0.19% |
-- |
-- |
2019-03-31
|
| Bayview Asset Management Co., Ltd. |
40500 |
0.22% |
40500 |
-- |
2019-04-30
|
| Equilibria Management & Research Ltd |
28392 |
0.20% |
28392 |
-- |
2018-11-30
|
| Sowell Financial Services, LLC |
15714 |
0.11% |
-- |
-- |
2018-06-30
|
| Millennium Management LLC |
13705 |
0.10% |
-4567 |
-24.99% |
2018-03-31
|
| Nivalis Therapeutics Inc |
3803906 |
6.85% |
3803906 |
-- |
2017-07-24
|
| RS Investment Management Co. LLC |
29987 |
0.22% |
-- |
-- |
2018-06-30
|
| BlackRock Institutional Trust Company NA |
11820 |
0.08% |
-- |
-- |
2018-06-30
|
| Spark Investment Management LLC |
13600 |
0.10% |
-3000 |
-18.07% |
2018-03-31
|
| Panagora Asset Management Inc |
7863 |
0.06% |
7863 |
-- |
2017-12-31
|
| Oxford Asset Management, LLC |
11919 |
0.09% |
-550 |
-4.41% |
2017-12-31
|
| Rock Springs Capital Management LP |
150000 |
1.08% |
-- |
-- |
2017-12-31
|
| Virtu Financial LLC |
12791 |
0.09% |
12791 |
-- |
2017-09-30
|
| SSgA Funds Management Inc |
5004 |
0.03% |
11 |
0.22% |
2018-03-05
|
| Acadian Asset Management LLC |
2265 |
0.02% |
2265 |
-- |
2017-09-30
|
| Mellon Capital Management Corporation |
2290 |
0.02% |
874 |
61.72% |
2017-09-30
|
| J.P. Morgan Securities Inc |
2600 |
0.02% |
2600 |
-- |
2017-09-30
|
| 共同基金持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| BlackRock Extended Equity Market |
24214 |
0.08% |
729 |
3.10% |
2022-03-31
|
| Vanguard Total Stock Market Index Fund |
458029 |
1.51% |
-- |
-- |
2022-05-31
|
| iShares Russell 2000 ETF |
257722 |
0.85% |
440 |
0.17% |
2022-05-31
|
| Vanguard Extended Market Index Fund |
169911 |
0.56% |
-- |
-- |
2022-05-31
|
| Bridgeway Ultra Small Company Market Fd |
142811 |
0.47% |
-- |
-- |
2022-03-31
|
| iShares Russell 2000 Growth ETF |
100343 |
0.33% |
-116 |
-0.12% |
2022-05-31
|
| iShares Biotechnology ETF |
93561 |
0.31% |
-9974 |
-9.63% |
2022-05-31
|
| Fidelity |
64619 |
0.21% |
-- |
-- |
2022-04-30
|
| State Street Russell Small/Mid Cap |
50000 |
0.16% |
-- |
-- |
2022-05-31
|
| NT R2000 Growth Index Fund - NL |
35940 |
0.12% |
-4385 |
-10.87% |
2022-03-31
|
| NT R2000 Index Fund - DC - NL |
25498 |
0.08% |
768 |
3.11% |
2022-03-31
|
| State Street Russell Small Cap |
44286 |
0.15% |
-- |
-- |
2022-05-31
|
| NT R2000 Growth Index Fund - L |
26889 |
0.09% |
1298 |
5.07% |
2022-03-31
|
| NT Russell 2000 Growth Index Eq Strat |
26889 |
0.09% |
276 |
1.04% |
2022-03-31
|
| Schwab Small Cap Index Fund |
26917 |
0.09% |
-- |
-- |
2022-05-31
|
| iShares Micro-Cap ETF |
27662 |
0.09% |
1040 |
3.91% |
2022-05-31
|
| ALPS Medical Breakthroughs ETF |
28284 |
0.09% |
-- |
-- |
2022-05-31
|
| Vanguard Russell 2000 Index Fund |
30023 |
0.10% |
-639 |
-2.08% |
2022-05-31
|
| NT R2000 Index Fund - NL |
34473 |
0.11% |
-3364 |
-8.89% |
2022-03-31
|
| iShares Russell 2000 Small-Cap Index Fd |
25129 |
0.08% |
-- |
-- |
2022-02-28
|
| Xtrackers MSCI Eurp CnsmerStpESGScrnETF |
80629 |
0.28% |
80629 |
-- |
2021-05-31
|
| WellsFargo Factor Enh US SC Eq CIT |
24916 |
0.09% |
24916 |
-- |
2021-09-30
|
| Allspring Factor Enh US SC Eq CIT |
24916 |
0.09% |
24916 |
-- |
2021-09-30
|
| Wells Fargo Factor Enh US SC Eq CIT |
24916 |
0.09% |
24916 |
-- |
2021-09-30
|
| Xtrackers Stoxx Eurp 600 Food&Bev Sp ETF |
80629 |
0.34% |
80629 |
-- |
2021-05-31
|
| SPDR |
21290 |
0.09% |
-350 |
-1.62% |
2021-07-31
|
| DFA US Core Equity II Fund |
19427 |
0.08% |
-- |
-- |
2021-06-30
|
| Russell 2000 Index Non-Lendable Fund E |
18313 |
0.08% |
18313 |
-- |
2021-06-30
|
| HW Micro Cap |
16400 |
0.07% |
6000 |
57.69% |
2021-06-30
|
| NT Ext Equity Market Index Fund - L |
9280 |
0.04% |
-- |
-- |
2021-03-31
|
| Vanguard Instl Total Stock Market Idx Fd |
10081 |
0.04% |
-- |
-- |
2021-05-31
|
| Hancock Horizon Microcap Fund |
10400 |
0.04% |
-- |
-- |
2021-05-31
|
| State Street U.S. Extended Market Index |
10700 |
0.04% |
-- |
-- |
2021-05-31
|
| BlackRock Russell 2000 |
12677 |
0.05% |
12677 |
-- |
2021-06-30
|
| BlackRock Russell 2500 |
13140 |
0.05% |
13140 |
-- |
2021-06-30
|
| Xtrackers Stoxx Eurp 600 Utilts Swap ETF |
46533 |
0.19% |
46533 |
-- |
2021-05-31
|
| NT Extended Equity Market Idx Fd - NL |
8783 |
0.04% |
742 |
9.23% |
2021-03-31
|
| NT Ext Equity Mkt Idx Fd - DC - NL |
6565 |
0.03% |
904 |
15.97% |
2021-03-31
|
| Vanguard Balanced Index Fund |
5130 |
0.02% |
-- |
-- |
2021-05-31
|
| T. Rowe Price U.S. Equities Tr |
5500 |
0.02% |
5500 |
-- |
2021-03-31
|
| DFA US Core Equity 1 Portfolio |
6024 |
0.03% |
-- |
-- |
2021-04-30
|
| Schwab Total Stock Market Index Fund |
4137 |
0.02% |
4137 |
-- |
2021-03-31
|
| DFA US Vector Equity Fund |
5080 |
0.02% |
-- |
-- |
2021-03-31
|
| DFA US Micro Cap Portfolio |
3775 |
0.02% |
-- |
-- |
2021-03-31
|
| Pleiades Small Cap Equity Fund |
20389 |
0.09% |
20389 |
-- |
2020-12-31
|
| NT DJ US Complt Ttl Stk Mkt Idx Eq Strat |
4167 |
0.02% |
-977 |
-18.99% |
2020-06-30
|
| EAM Ultra Micro Cap |
63029 |
0.26% |
63029 |
-- |
2020-12-31
|
| Vanguard US Equity Index Fund |
2721 |
0.01% |
1895 |
229.42% |
2020-12-31
|
| The Vanguard Total Stock Market Index |
5438 |
0.02% |
-- |
-- |
2020-11-30
|
| SEI GMF US Small Companies Fund |
67545 |
0.28% |
-24455 |
-26.58% |
2020-08-31
|
| SEI Small Cap (SIMT) Fund |
56791 |
0.24% |
-4209 |
-6.90% |
2020-08-31
|
| SEI Tax-Managed Small/Mid Cap (SIMT) Fd |
80000 |
0.34% |
12675 |
18.83% |
2020-08-31
|
| Dimensional Global Core Equity |
1700 |
0.01% |
-- |
-- |
2020-03-31
|
| DFA T.A. US Core Equity 2 Portfolio |
1694 |
0.01% |
-- |
-- |
2020-06-30
|
| Vericimetry US Small Cap Value Fund |
9900 |
0.05% |
9900 |
-- |
2019-12-31
|
| DFA US Targeted Value Portfolio |
5443 |
0.03% |
-- |
-- |
2020-03-31
|
| NT Extended Equity Market Idx Fund - NL |
3991 |
0.02% |
-- |
-- |
2020-03-31
|
| VALIC Company I Small Cap Fund |
3750 |
0.02% |
-- |
-- |
2019-12-31
|
| Victory RS Science and Technology Fund |
65297 |
0.35% |
-- |
-- |
2019-09-30
|
| NT Ext Equity Mkt Fd - DC - NL |
2856 |
0.02% |
208 |
7.85% |
2019-06-30
|
| 1290 VT Micro Cap Portfolio |
822 |
-- |
-- |
-- |
2019-01-31
|
| iShares Core S&P Total US Stock Mkt ETF |
718 |
-- |
-- |
-- |
2019-03-29
|
| DFA Tax-Managed US Targeted Value Port |
2695 |
0.01% |
-- |
-- |
2018-12-31
|
| Invesco Wilshire Micro-Cap ETF |
1914 |
0.01% |
-- |
-- |
2018-12-31
|
| Bayview US Bio Venture MF |
40500 |
0.29% |
40500 |
-- |
2018-02-09
|
| Wells Fargo Factor Enhanced Sm Cp IdxCIT |
3701 |
0.03% |
464 |
14.33% |
2018-03-31
|
| Wells Fargo Factor Enhanced Small Cap |
3244 |
0.02% |
-126 |
-3.74% |
2018-05-31
|
| Avance Global FI |
28392 |
0.20% |
28392 |
-- |
2017-08-31
|
| iShares Micro-Cap |
12684 |
0.09% |
-- |
-- |
2018-09-12
|
| Fidelity Spartan |
12084 |
0.09% |
-- |
-- |
2018-07-31
|
| Vanguard Instl Ttl Stk Mkt Idx InstlPls |
15920 |
0.11% |
-- |
-- |
2018-07-31
|
| Vanguard Extended Market Idx Inv |
27198 |
0.20% |
8200 |
43.16% |
2018-07-31
|
| RS Technology A |
29987 |
0.22% |
-- |
-- |
2018-06-30
|
| Bridgeway Ultra-Small Company Market |
35000 |
0.25% |
-- |
-- |
2018-06-30
|
| Vanguard Total Stock Mkt Idx |
180890 |
1.31% |
-- |
-- |
2018-07-31
|
| DFA T.A. US Core Equity 2 I |
1694 |
0.01% |
-- |
-- |
2018-07-31
|
| DFA US Core Equity 2 I |
11076 |
0.08% |
1501 |
15.68% |
2018-07-31
|
| DFA US Targeted Value I |
5443 |
0.04% |
-- |
-- |
2018-07-31
|
| DFA US Micro Cap I |
3775 |
0.03% |
-- |
-- |
2018-07-31
|
| Wilshire Micro-Cap ETF |
2732 |
0.02% |
-- |
-- |
2018-09-14
|
| DFA Tax-Managed US Targeted Value |
2695 |
0.02% |
-- |
-- |
2018-07-31
|
| BlackRock Extended Equity Market K |
3124 |
0.02% |
85 |
2.80% |
2018-06-30
|
| VALIC Company I Small Cap |
3750 |
0.03% |
-- |
-- |
2018-07-31
|
| DFA US Core Equity 1 I |
3872 |
0.03% |
2169 |
127.36% |
2018-07-31
|
| DFA US Vector Equity I |
5080 |
0.04% |
-- |
-- |
2018-07-31
|
| BNY Mellon EB DL Mkt Completion |
1145 |
0.01% |
-- |
-- |
2018-03-31
|
| AXA/Lord Abbett Micro Cap K |
822 |
0.01% |
-- |
-- |
2018-04-30
|
| Vanguard Balanced Index Inv |
3918 |
0.03% |
-- |
-- |
2018-04-30
|
| Wells Fargo Dow Jones Target 2040 A |
671 |
-- |
-105 |
-13.53% |
2018-01-31
|
| BNY Mellon Market Completion Fund UC1 |
1145 |
0.01% |
874 |
322.51% |
2017-09-30
|
| iShares Core S&P Total US Stock Mkt |
718 |
0.01% |
-- |
-- |
2018-01-30
|
