| 开盘价:-- |
最高价:-- |
最低价:-- |
52周最高价:-- |
52周最低价:-- |
| 成交量:-- |
平均成交量:-- |
市值:-- |
市盈率:-- |
预期市盈率:-- |
| 每股收益:-- |
贝塔系数:-- |
股息:-- |
收益率:-- |
总股本:-- |
| 机构持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| Pictet Asset Management S.A. |
1556877 |
1.04% |
27066 |
1.77% |
2022-05-31
|
| Point72 Asset Management, L.P. |
9362451 |
6.27% |
-2492700 |
-21.03% |
2022-03-31
|
| Gilde Healthcare Holding BV |
8125000 |
5.44% |
8125000 |
-- |
2022-04-18
|
| Ridgeback Capital Investments L.p. |
7722106 |
5.17% |
7722106 |
-- |
2021-12-31
|
| BlackRock Inc |
6848983 |
4.59% |
70893 |
1.05% |
2021-12-31
|
| 683 Capital Management LLC |
6140000 |
4.11% |
239441 |
4.06% |
2022-03-31
|
| Baker Bros Advisors LP |
5153169 |
3.45% |
2500000 |
94.23% |
2022-03-31
|
| NEA Management Company, LLC |
4426488 |
2.96% |
-- |
-- |
2022-03-31
|
| Citadel Advisors Llc |
3886673 |
2.60% |
64278 |
1.68% |
2022-03-31
|
| Pictet Asset Management Ltd |
2585282 |
1.73% |
-110470 |
-4.10% |
2022-05-31
|
| Granahan Investment Management Inc.. |
2536928 |
1.70% |
-842448 |
-24.93% |
2022-03-31
|
| Nuveen Asset Management, LLC |
1638485 |
1.10% |
61946 |
3.93% |
2022-03-31
|
| Healthcor Management LP |
1721925 |
1.15% |
-- |
-- |
2022-03-31
|
| State Street Corporation |
2112912 |
1.42% |
67761 |
3.31% |
2022-03-31
|
| Teachers Advisors LLC |
2148915 |
1.44% |
175180 |
8.88% |
2022-05-31
|
| Fidelity Management & Research Company LLC |
2350839 |
1.57% |
-8198 |
-0.35% |
2022-05-31
|
| Jackson National Asset Management LLC |
2410339 |
1.61% |
229338 |
10.52% |
2022-05-31
|
| BlackRock Fund Advisors |
4928522 |
3.30% |
-8540 |
-0.17% |
2022-05-31
|
| Granahan Investment Management Inc |
2424286 |
1.62% |
-530599 |
-17.96% |
2022-05-31
|
| Bain Capital Public Equity Management II, LLC |
2373099 |
1.59% |
1225093 |
106.71% |
2021-12-31
|
| Goldman Sachs Group Inc |
1574300 |
1.05% |
-1271900 |
-44.69% |
2021-12-31
|
| Morgan Stanley Investment Management, Inc. |
4653503 |
3.88% |
4653503 |
-- |
2020-12-31
|
| Northern Trust Investments Inc |
1557234 |
1.30% |
-7784 |
-0.50% |
2022-01-31
|
| Vanguard Group Inc |
1367063 |
1.14% |
402630 |
41.75% |
2021-09-30
|
| HBM Partners Cayman Ltd |
1327597 |
1.11% |
268000 |
25.29% |
2022-01-31
|
| FMR Inc |
1249400 |
1.04% |
33905 |
2.79% |
2021-09-30
|
| Sphera Funds Management Ltd. |
1276702 |
1.07% |
257737 |
25.29% |
2021-06-30
|
| Consonance Capital Management LP |
3176418 |
2.65% |
-2832556 |
-47.14% |
2021-06-30
|
| Fundlogic SAS |
2921494 |
2.44% |
253239 |
9.49% |
2021-03-31
|
| Morgan Stanley - Brokerage Accounts |
3522617 |
2.96% |
-1130886 |
-24.30% |
2021-03-31
|
| Millennium Management LLC |
1968588 |
1.65% |
-264529 |
-11.85% |
2021-03-31
|
| Bank of America Corp |
1659703 |
1.40% |
1296932 |
357.51% |
2020-12-31
|
| Acadian Asset Management LLC |
1852602 |
1.56% |
1657271 |
848.44% |
2020-12-31
|
| Eversept Partners, LLC |
1245458 |
1.09% |
302469 |
32.08% |
2020-09-30
|
| Fidelity Management and Research Company |
1193295 |
1.04% |
-28981 |
-2.37% |
2020-12-31
|
| Growth Equity Opportunities Fund IV, LLC |
6126488 |
5.34% |
6126488 |
-- |
2019-11-08
|
| Deutsche Bank AG |
1200681 |
1.05% |
1163415 |
3121.92% |
2020-09-30
|
| DWS Investments UK Limited |
1197200 |
1.04% |
1163415 |
3443.58% |
2020-09-30
|
| Dafna Capital Management LLC |
924278 |
0.94% |
79278 |
9.38% |
2020-09-30
|
| Fidelity Management & Research Company LLC |
2494669 |
2.82% |
198948 |
8.67% |
2020-11-30
|
| Sio Capital Management, LLC |
933150 |
1.10% |
-85050 |
-8.35% |
2020-06-30
|
| State Street Global Advisors |
745061 |
0.88% |
15254 |
2.09% |
2020-07-31
|
| Wellington Management Company LLP |
2864698 |
3.39% |
-2936524 |
-50.62% |
2020-03-31
|
| Stonepine Capital Management Llc |
3000000 |
3.55% |
-1010155 |
-25.19% |
2020-03-31
|
| AQR Capital Management LLC |
1097885 |
1.76% |
34994 |
3.29% |
2020-03-31
|
| Northern Trust Corp |
714877 |
1.14% |
48721 |
7.31% |
2020-03-31
|
| Geode Capital Management, LLC |
631901 |
1.01% |
-690261 |
-52.21% |
2020-03-31
|
| Northern Trust Investments N A |
714877 |
1.14% |
48721 |
7.31% |
2020-03-31
|
| Fidelity Management & Research Company |
2490728 |
3.99% |
261253 |
11.72% |
2020-05-31
|
| Carmignac Gestion Luxembourg S.A. |
1368315 |
2.19% |
-583778 |
-29.91% |
2020-02-29
|
| Oxford Asset Management, LLC |
804778 |
1.29% |
-373788 |
-31.72% |
2019-09-30
|
| New Leaf Venture Partners, L.L.C. |
732774 |
1.17% |
-- |
-- |
2019-06-30
|
| Telemetry Investments, L.L.C. |
684039 |
1.10% |
329039 |
92.69% |
2019-06-30
|
| Nationwide Fund Advisors |
349260 |
0.56% |
25199 |
7.78% |
2019-10-31
|
| Carmignac Gestion |
1368315 |
2.19% |
-771178 |
-36.04% |
2019-06-30
|
| Brookside Capital Management LLC |
1506595 |
2.41% |
-856218 |
-36.24% |
2019-03-31
|
| TIAA Investments |
376012 |
0.60% |
188044 |
100.04% |
2019-09-30
|
| Tekla Capital Management LLC |
254000 |
0.41% |
-- |
-- |
2019-06-30
|
| Dimensional Fund Advisors, Inc. |
309727 |
0.50% |
-- |
-- |
2019-06-30
|
| EAM Global Investors, LLC |
322240 |
0.52% |
-- |
-- |
2019-03-31
|
| Dimensional Fund Advisors LP |
223631 |
0.36% |
-- |
-- |
2019-07-31
|
| California Public Employees Retrmnt Sys |
175000 |
0.28% |
-- |
-- |
2019-03-31
|
| Carmignac Gestion Luxembourg |
1014367 |
1.62% |
-- |
-- |
2019-05-31
|
| Orbimed Advisors, LLC |
326650 |
0.52% |
-- |
-- |
2018-12-31
|
| NEA 15 GP, LLC |
5138888 |
8.23% |
5138888 |
-- |
2018-02-13
|
| Morgan Stanley & Co Inc |
407934 |
0.65% |
-6654 |
-1.60% |
2018-09-30
|
| Kennedy Capital Management Inc |
740783 |
1.19% |
740783 |
-- |
2018-03-31
|
| CVI Holdings LLC |
360455 |
0.58% |
360455 |
-- |
2018-03-31
|
| Crestline Management LP |
334166 |
0.54% |
334166 |
-- |
2018-03-31
|
| Iguana Healthcare Management, LLC |
300000 |
0.48% |
300000 |
-- |
2018-03-31
|
| DRW Securities, LLC |
120000 |
0.19% |
10000 |
9.09% |
2018-06-30
|
| AGUTH Holding GmbH |
8924563 |
14.30% |
-- |
-- |
2018-03-20
|
| Hawkes Bay Master Investors (Cayman) LP |
1809480 |
4.05% |
-372205 |
-17.06% |
2017-12-29
|
| Renaissance Technologies Corp |
177510 |
0.28% |
49610 |
38.79% |
2018-06-30
|
| Creative Planning Inc |
106900 |
0.17% |
6900 |
6.90% |
2018-03-31
|
| Wells Fargo Advisors, LLC |
83427 |
0.13% |
22193 |
36.24% |
2018-03-31
|
| TWO SIGMA SECURITIES, LLC |
104512 |
0.22% |
104512 |
-- |
2017-12-31
|
| Moore Capital Management, LP |
125000 |
0.27% |
-125000 |
-50.00% |
2017-12-31
|
| Perceptive Advisors LLC |
668214 |
1.43% |
-- |
-- |
2017-12-31
|
| Soci¨?t¨? G¨?n¨?rale Gestion |
50600 |
0.09% |
-- |
-- |
2018-02-28
|
| United of Omaha Life Insurance |
47900 |
0.14% |
47900 |
-- |
2016-12-31
|
| Muhlenkamp & CO Inc |
61000 |
0.14% |
-1535 |
-2.45% |
2017-12-31
|
| KCG AMERICAS LLC |
70439 |
0.16% |
70439 |
-- |
2017-06-30
|
| Susquehanna Financial Group, LLLP |
45745 |
0.10% |
10489 |
29.75% |
2017-06-30
|
| LSP III Management B V |
1493199 |
4.49% |
-68204 |
-4.37% |
2015-12-31
|
| Opaleye Management Inc |
430000 |
1.29% |
-165000 |
-27.73% |
2016-09-30
|
| Frigate Ventures LP |
363161 |
1.09% |
-- |
-- |
2016-09-30
|
| Lombard Odier Asset Management USA Corp |
350989 |
1.06% |
-14688 |
-4.02% |
2016-09-30
|
| Goldman, Sachs & Co. |
53748 |
0.16% |
-8683 |
-13.91% |
2016-09-30
|
| Novo-Nordisk A/S |
2862460 |
8.61% |
128446 |
4.70% |
2015-12-31
|
| Frank Mühlenbeck |
5889209 |
3.00% |
36218635 |
0.20% |
1999-11-30
|
| Entities affiliated with Life Sciences Partners |
1561403 |
3.00% |
9602628 |
0.10% |
1999-11-30
|
| BioMedInvest I Ltd. |
1561595 |
3.00% |
9603809 |
0.10% |
1999-11-30
|
| Wellington Management Group LLP |
1947631 |
3.00% |
11977931 |
0.10% |
1999-11-30
|
| Novo Nordisk A/S |
2734014 |
3.00% |
16814186 |
0.10% |
1999-11-30
|
| Michael B. Sheffery |
5814630 |
3.00% |
35759974 |
0.20% |
1999-11-30
|
| 共同基金持股 |
| 持有者 |
持有份额 |
持股比例 |
份额变化 |
变化率 |
报告日期 |
| NT R2000 Growth Index Fund - NL |
352272 |
0.24% |
-50015 |
-12.43% |
2022-03-31
|
| NT R2000 Index Fund - NL |
337890 |
0.23% |
-39576 |
-10.48% |
2022-03-31
|
| iShares Russell 2000 ETF |
2594011 |
1.74% |
4400 |
0.17% |
2022-05-31
|
| Pictet-Biotech |
2585282 |
1.73% |
-110470 |
-4.10% |
2021-11-30
|
| Pictet-Global Megatrend Selection |
1556877 |
1.04% |
27066 |
1.77% |
2021-11-30
|
| HBM Healthcare Investments AG |
1327597 |
0.89% |
-- |
-- |
2022-03-31
|
| Granahan US SMID Select Fund |
1297585 |
0.87% |
37894 |
3.01% |
2022-05-31
|
| JNL Multi-Manager Small Cap Growth Fund |
1051159 |
0.70% |
-339584 |
-24.42% |
2022-03-31
|
| iShares Biotechnology ETF |
1031278 |
0.69% |
-11410 |
-1.09% |
2022-05-31
|
| iShares Russell 2000 Growth ETF |
985585 |
0.66% |
-1135 |
-0.12% |
2022-05-31
|
| Arctic Aurora LifeScience |
977634 |
0.65% |
577000 |
144.02% |
2022-04-30
|
| TIAA-CREF Quant Small-Cap Equity Fund |
833056 |
0.56% |
930 |
0.11% |
2022-04-30
|
| Granahan Small/Mid Cap Select |
742299 |
0.50% |
-256709 |
-25.70% |
2022-03-31
|
| Fidelity |
594887 |
0.40% |
-- |
-- |
2022-04-30
|
| Vanguard Explorer Fund |
592606 |
0.40% |
-- |
-- |
2022-03-31
|
| State Street Russell Small/Mid Cap |
558632 |
0.37% |
-- |
-- |
2022-05-31
|
| Nomura World Genome Tech Open Mother |
516400 |
0.35% |
516400 |
-- |
2021-11-18
|
| State Street Russell Small Cap |
438731 |
0.29% |
-- |
-- |
2022-05-31
|
| Tekla Healthcare Investors |
367414 |
0.25% |
-- |
-- |
2021-12-31
|
| Fidelity Advisor |
337485 |
0.27% |
-- |
-- |
2022-02-28
|
| SPDR |
316210 |
0.26% |
1014 |
0.32% |
2022-03-31
|
| Vanguard Russell 2000 Index Fund |
312853 |
0.26% |
13288 |
4.44% |
2022-02-28
|
| Janus Henderson Horizon Biotechnology |
301765 |
0.25% |
-- |
-- |
2021-11-30
|
| NT R2000 Index Fund - DC - NL |
293533 |
0.25% |
-9201 |
-3.04% |
2021-09-30
|
| M&G (ACS) Granahan US Small Cap Gr Fd |
333893 |
0.28% |
333893 |
-- |
2021-08-31
|
| iShares Micro-Cap ETF |
279868 |
0.23% |
-- |
-- |
2021-10-29
|
| Tekla World Healthcare Fund |
332698 |
0.28% |
332698 |
-- |
2021-06-30
|
| USAA Small Cap Stock Fund |
342965 |
0.29% |
-23150 |
-6.32% |
2021-06-30
|
| Small Cap Select Opportunities |
1099496 |
0.92% |
906623 |
470.06% |
2021-06-30
|
| Granahan Inv Mgt - Sm-Cap Core Gr |
342965 |
0.29% |
-23150 |
-6.32% |
2021-06-30
|
| CREF Stock Account |
292874 |
0.25% |
78700 |
36.75% |
2021-05-31
|
| NT R2000 Growth Index Fund - L |
280106 |
0.24% |
32935 |
13.32% |
2021-03-31
|
| Granahan Small Cap Advantage |
269584 |
0.23% |
-114400 |
-29.79% |
2021-03-31
|
| iShares Nasdaq Biotechnology ETF |
975734 |
0.82% |
-4392 |
-0.45% |
2021-05-28
|
| Acadian Non-U.S. Small-Cap Equity Compst |
324090 |
0.27% |
-- |
-- |
2020-06-30
|
| NT Russell 2000 Growth Index Eq Strat |
237162 |
0.21% |
47637 |
25.13% |
2020-06-30
|
| EAM Micro Cap |
252527 |
0.22% |
252527 |
-- |
2020-12-31
|
| BlackRock Advantage Small Cap Growth Fd |
174408 |
0.18% |
-- |
-- |
2020-11-30
|
| Schwab Small Cap Index Fund |
168666 |
0.17% |
-- |
-- |
2020-11-30
|
| Acadian Non-US Small-Cap Developed Eqty |
324090 |
0.38% |
93207 |
40.37% |
2020-06-30
|
| Schwab Small-Cap Equity Fund |
180950 |
0.21% |
-- |
-- |
2020-06-30
|
| AQR Capital Small Cap Core |
275559 |
0.44% |
204902 |
290.00% |
2020-03-31
|
| Pacific Select International Sm-Cp Port |
255400 |
0.41% |
-- |
-- |
2020-04-30
|
| Bridgeway Ultra Small Company Fund |
369300 |
0.59% |
113500 |
44.37% |
2019-12-31
|
| NT R2000 Growth Index Fund - Non-Lending |
267788 |
0.43% |
-- |
-- |
2020-03-31
|
| Northern Trust Russell 2000 Index DC NL |
216912 |
0.35% |
6834 |
3.25% |
2020-03-31
|
| Nationwide International Small Cap Fund |
196417 |
0.31% |
-132800 |
-40.34% |
2020-03-31
|
| NT R2000 Growth Index Fund - Lending |
189525 |
0.30% |
-- |
-- |
2020-03-31
|
| Tekla Life Sciences Investors |
254000 |
0.41% |
-- |
-- |
2019-06-30
|
| Carmignac Pf Long-Short European Eq |
767293 |
1.23% |
-336579 |
-30.49% |
2019-06-30
|
| Carmignac Long-Short European Equities |
601022 |
0.96% |
-247199 |
-29.14% |
2019-06-30
|
| Russell Inv US Small Cap Equity Fund |
193154 |
0.31% |
-- |
-- |
2019-10-31
|
| MEDICAL BioHealth |
130000 |
0.21% |
-- |
-- |
2019-06-30
|
| Russell 2000 Index Non-Lendable Fund E |
118777 |
0.19% |
118777 |
-- |
2019-06-30
|
| BB Adamant Global Biotech |
107500 |
0.17% |
-- |
-- |
2019-06-30
|
| Wellington CIF II SMID Cap Research |
168243 |
0.27% |
-72583 |
-30.14% |
2018-11-30
|
| iShares Russell 2000 Value ETF |
92710 |
0.15% |
189 |
0.20% |
2019-07-31
|
| APO Medical Opportunities |
90000 |
0.14% |
-- |
-- |
2019-06-30
|
| iShares Russell 2000 Small-Cap Index Fd |
89911 |
0.14% |
89911 |
-- |
2019-06-30
|
| DFA US Small Cap Portfolio |
89567 |
0.14% |
-- |
-- |
2019-05-31
|
| Wellington Small Cap 2000 Tr |
87134 |
0.14% |
-- |
-- |
2019-03-31
|
| DFA US Core Equity II Fund |
86693 |
0.14% |
-- |
-- |
2019-05-31
|
| Bellevue (Lux) BB Adamant Biotech |
60000 |
0.10% |
-- |
-- |
2018-12-31
|
| MutOma-Wellington Small Company Fund |
46954 |
0.08% |
10187 |
27.71% |
2019-01-31
|
| DFA US Core Equity 1 Portfolio |
28571 |
0.05% |
-- |
-- |
2019-05-31
|
| MO Wellington Small Company Fund |
46954 |
0.08% |
10187 |
27.71% |
2019-01-31
|
| apo Medical Opportunities Institutionell |
24000 |
0.04% |
-- |
-- |
2019-05-31
|
| RIM Global Bioscience |
18100 |
0.03% |
-- |
-- |
2019-04-30
|
| GlobalAccess US Small & Mid Cap Eq Fd |
16119 |
0.03% |
-- |
-- |
2019-02-28
|
| SWC (CH) Equity Fund Glb Health Care |
12048 |
0.02% |
12048 |
-- |
2018-11-30
|
| DFA US Micro Cap Portfolio |
9800 |
0.02% |
-- |
-- |
2019-01-31
|
| Hillsdale US Small Cap Equity Fund |
15000 |
0.02% |
15000 |
-- |
2018-09-30
|
| Hillsdale US Performance Equity (US$) |
15000 |
0.02% |
15000 |
-- |
2018-09-30
|
| DFA US Sustainability Core 1 Portfolio |
9000 |
0.01% |
-- |
-- |
2019-01-31
|
| Hillsdale Global Performance Equity Fund |
8188 |
0.01% |
8188 |
-- |
2018-09-30
|
| FCP MEDICAL BioHealth-Trends |
130000 |
0.21% |
69000 |
113.11% |
2018-10-31
|
| RIM Global CC Bioscience |
9100 |
0.01% |
-- |
-- |
2018-11-30
|
| SG Actions US Techno |
37100 |
0.06% |
-- |
-- |
2018-09-30
|
| Dimensional US Small Companies Fund |
5844 |
0.01% |
-- |
-- |
2018-06-30
|
| Pru Ret Small Cap Value/Kennedy SP |
283397 |
0.45% |
283397 |
-- |
2018-03-31
|
| Wellington CIF II Small Cap 2000 S1 |
128979 |
0.21% |
-- |
-- |
2018-06-30
|
| DFA US Small Cap I |
89567 |
0.14% |
-- |
-- |
2018-07-31
|
| DFA US Core Equity 2 I |
86693 |
0.14% |
-- |
-- |
2018-07-31
|
| DFA US Core Equity 1 I |
28571 |
0.05% |
-- |
-- |
2018-07-31
|
| DFA US Micro Cap I |
9800 |
0.02% |
-- |
-- |
2018-07-31
|
| DFA US Sustainability Core 1 |
9000 |
0.01% |
-- |
-- |
2018-07-31
|
| SA US Small Company |
5000 |
0.01% |
-- |
-- |
2018-02-28
|
| Tocqueville Opportunity |
4500 |
0.01% |
-- |
-- |
2017-09-30
|
| State Street Russell Small Cap Growth Idx Cl A |
1600 |
-- |
-- |
-- |
2015-12-31
|
| Fidelity® Select Pharmaceuticals Port |
436100 |
1.80% |
25000 |
6.10% |
2015-09-30
|
| Candriam Eqs L Biotechnology |
263000 |
1.10% |
-- |
-- |
2015-09-30
|
| iShares Russell 2000 (AU) |
240574 |
0.90% |
-306 |
-0.10% |
2015-11-19
|
| Fidelity Advisor® Biotechnology Fund |
172850 |
0.70% |
-- |
-- |
2015-09-30
|
| iShares Russell 2000 Growth |
119394 |
0.50% |
-- |
-- |
2015-11-19
|
| TFS Market Neutral Fund |
60531 |
0.20% |
-89462 |
-59.60% |
2015-07-31
|
| ALPS Medical Breakthroughs ETF |
46082 |
0.20% |
-457 |
-1.00% |
2015-10-31
|
| Polar Capital Biotechnology Fund |
38921 |
0.20% |
-4629 |
-10.60% |
2015-10-31
|
| iShares Micro-Cap |
37195 |
0.20% |
-- |
-- |
2015-11-19
|
| Northern Trust Russell 2000 Index Fund - DC - Non-Lending |
32473 |
0.10% |
-1430 |
-4.20% |
2015-09-30
|
| BioShares Biotechnology Clncl Trls Fd |
27836 |
0.10% |
-- |
-- |
2015-11-19
|
